ea0049ep60 | Adrenal cortex (to include Cushing's) | ECE2017
Pilli Tania
, Forleo Raffaella
, Cardinale Sandro
, Cenci Valeria
, Pacini Furio
Introduction: Adrenal insufficiency is a life-threatening disease. Conventional treatment requires multiple daily doses of immediate-release hydrocortisone or cortisone acetate causing non-physiological peaks and nadir of cortisol and it has been also associated with premature mortality, high frequency of infections, reduced quality of life, altered metabolic profile and reduced bone mineral density. A modified-release hydrocortisone (Plenadren®, Shire) by combining a rap...